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BHLHE23

GENERAL INFORMATION

Gene name

 BHLHE23

Gene description

 Basic helix-loop-helix family, member e23

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Not detected
FANTOM5:Not detected

Protein evidence

 Evidence at transcript level

Protein expression

 RNA-based expert annotation gave inconclusive results.

DATA RELIABILITY

Data reliability
description

 No RNA expression data detected and pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA030575
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 BHLHE23 (HGNC Symbol)

Synonyms

 bA305P22.3, Beta4, BHLHB4, bHLHe23

Description

 Basic helix-loop-helix family, member e23 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63005927 - 63007035

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000125533 (version 83.38)

Entrez gene

 128408

UniProt

 Q8NDY6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NDY6

Antibodypedia

 BHLHE23 antibodies

PROTEIN BROWSER
BHLHE23-001
BHLHE23-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BHLHE23-001
ENSP00000480998
ENST00000612929
A0A087WXG3 [Direct mapping]
Class E basic helix-loop-helix protein 23
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Predicted intracellular proteins
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GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046548 [retinal rod cell development]
GO:0046671 [negative regulation of retinal cell programmed cell death]
GO:0046983 [protein dimerization activity]
GO:0048050 [post-embryonic eye morphogenesis]
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 241 aa
25.2 kDa 		No 0
BHLHE23-201
ENSP00000359371
ENST00000370346
Q8NDY6 [Direct mapping]
Class E basic helix-loop-helix protein 23
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Predicted intracellular proteins
Transcription factors
   Basic domains
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
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 225 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.