We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
IL1B
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

IL1B

Gene description

Interleukin 1, beta

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (BJ hTERT+, HMC-1, U-87 MG)
HPA (normal tissue):Tissue enhanced (appendix, bone marrow)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

IL1B (HGNC Symbol)

Synonyms

IL-1B, IL1-BETA, IL1F2

Description

Interleukin 1, beta (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.1

Chromosome location (bp)

112829751 - 112836903

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125538 (version 83.38)

Entrez gene

3553

UniProt

P01584 (UniProt - Evidence at protein level)

neXtProt

NX_P01584

Antibodypedia

IL1B antibodies

PROTEIN BROWSER

IL1B-001
IL1B-003
IL1B-006
IL1B-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL1B-001
ENSP00000263341
ENST00000263341
P01584 [Direct mapping]
Interleukin-1 beta
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001660 [fever generation]
GO:0001666 [response to hypoxia]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002439 [chronic inflammatory response to antigenic stimulus]
GO:0002711 [positive regulation of T cell mediated immunity]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0008210 [estrogen metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0009100 [glycoprotein metabolic process]
GO:0009408 [response to heat]
GO:0009743 [response to carbohydrate]
GO:0010193 [response to ozone]
GO:0010243 [response to organonitrogen compound]
GO:0010332 [response to gamma radiation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010829 [negative regulation of glucose transport]
GO:0010942 [positive regulation of cell death]
GO:0014050 [negative regulation of glutamate secretion]
GO:0014070 [response to organic cyclic compound]
GO:0014805 [smooth muscle adaptation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019742 [pentacyclic triterpenoid metabolic process]
GO:0019904 [protein domain specific binding]
GO:0030141 [secretory granule]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030593 [neutrophil chemotaxis]
GO:0030638 [polyketide metabolic process]
GO:0030728 [ovulation]
GO:0030730 [sequestering of triglyceride]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031622 [positive regulation of fever generation]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0032611 [interleukin-1 beta production]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0033092 [positive regulation of immature T cell proliferation in thymus]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0033198 [response to ATP]
GO:0033280 [response to vitamin D]
GO:0033591 [response to L-ascorbic acid]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0035066 [positive regulation of histone acetylation]
GO:0035176 [social behavior]
GO:0035234 [ectopic germ cell programmed cell death]
GO:0035505 [positive regulation of myosin light chain kinase activity]
GO:0035634 [response to stilbenoid]
GO:0035690 [cellular response to drug]
GO:0036270 [response to diuretic]
GO:0036273 [response to statin]
GO:0042060 [wound healing]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0042493 [response to drug]
GO:0043065 [positive regulation of apoptotic process]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043278 [response to morphine]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043434 [response to peptide hormone]
GO:0043491 [protein kinase B signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045080 [positive regulation of chemokine biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045471 [response to ethanol]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045687 [positive regulation of glial cell differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045833 [negative regulation of lipid metabolic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0050766 [positive regulation of phagocytosis]
GO:0050768 [negative regulation of neurogenesis]
GO:0050796 [regulation of insulin secretion]
GO:0050900 [leukocyte migration]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0050996 [positive regulation of lipid catabolic process]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051384 [response to glucocorticoid]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0060559 [positive regulation of calcidiol 1-monooxygenase activity]
GO:0070062 [extracellular exosome]
GO:0070164 [negative regulation of adiponectin secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070487 [monocyte aggregation]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071236 [cellular response to antibiotic]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071310 [cellular response to organic substance]
GO:0071333 [cellular response to glucose stimulus]
GO:0071396 [cellular response to lipid]
GO:0071398 [cellular response to fatty acid]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071414 [cellular response to methotrexate]
GO:0071548 [response to dexamethasone]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:2000173 [negative regulation of branching morphogenesis of a nerve]
GO:2000178 [negative regulation of neural precursor cell proliferation]
GO:2000778 [positive regulation of interleukin-6 secretion]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
269 aa
30.7 kDa
No 0
IL1B-003
ENSP00000407219
ENST00000418817
C9JWV2 [Direct mapping]
Interleukin-1 beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
Show all
143 aa
16.4 kDa
No 0
IL1B-006
ENSP00000400854
ENST00000416750
C9JVK0 [Direct mapping]
Interleukin-1 beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
Show all
111 aa
12.8 kDa
No 0
IL1B-007
ENSP00000409680
ENST00000432018
C9JSC2 [Direct mapping]
Interleukin-1 beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
Show all
125 aa
14.3 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.