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RNA tissue category: Tissue enhanced (appendix, bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GENE INFORMATION
Gene name
IL1B (HGNC Symbol)
Synonyms
IL-1B, IL1-BETA, IL1F2
Description
Interleukin 1, beta (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0001660 [fever generation] GO:0001666 [response to hypoxia] GO:0001934 [positive regulation of protein phosphorylation] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002437 [inflammatory response to antigenic stimulus] GO:0002439 [chronic inflammatory response to antigenic stimulus] GO:0002711 [positive regulation of T cell mediated immunity] GO:0005125 [cytokine activity] GO:0005149 [interleukin-1 receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005776 [autophagosome] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007267 [cell-cell signaling] GO:0007566 [embryo implantation] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0007611 [learning or memory] GO:0007613 [memory] GO:0008210 [estrogen metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0009100 [glycoprotein metabolic process] GO:0009408 [response to heat] GO:0009743 [response to carbohydrate] GO:0010193 [response to ozone] GO:0010243 [response to organonitrogen compound] GO:0010332 [response to gamma radiation] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010829 [negative regulation of glucose transport] GO:0010942 [positive regulation of cell death] GO:0014050 [negative regulation of glutamate secretion] GO:0014070 [response to organic cyclic compound] GO:0014805 [smooth muscle adaptation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019742 [pentacyclic triterpenoid metabolic process] GO:0019904 [protein domain specific binding] GO:0030141 [secretory granule] GO:0030213 [hyaluronan biosynthetic process] GO:0030593 [neutrophil chemotaxis] GO:0030638 [polyketide metabolic process] GO:0030728 [ovulation] GO:0030730 [sequestering of triglyceride] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031622 [positive regulation of fever generation] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0031982 [vesicle] GO:0032308 [positive regulation of prostaglandin secretion] GO:0032355 [response to estradiol] GO:0032496 [response to lipopolysaccharide] GO:0032611 [interleukin-1 beta production] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729 [positive regulation of interferon-gamma production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032874 [positive regulation of stress-activated MAPK cascade] GO:0033092 [positive regulation of immature T cell proliferation in thymus] GO:0033129 [positive regulation of histone phosphorylation] GO:0033198 [response to ATP] GO:0033280 [response to vitamin D] GO:0033591 [response to L-ascorbic acid] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0035066 [positive regulation of histone acetylation] GO:0035176 [social behavior] GO:0035234 [ectopic germ cell programmed cell death] GO:0035505 [positive regulation of myosin light chain kinase activity] GO:0035634 [response to stilbenoid] GO:0035690 [cellular response to drug] GO:0036270 [response to diuretic] GO:0036273 [response to statin] GO:0042060 [wound healing] GO:0042102 [positive regulation of T cell proliferation] GO:0042346 [positive regulation of NF-kappaB import into nucleus] GO:0042493 [response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043278 [response to morphine] GO:0043407 [negative regulation of MAP kinase activity] GO:0043434 [response to peptide hormone] GO:0043491 [protein kinase B signaling] GO:0043507 [positive regulation of JUN kinase activity] GO:0045080 [positive regulation of chemokine biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045410 [positive regulation of interleukin-6 biosynthetic process] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045471 [response to ethanol] GO:0045665 [negative regulation of neuron differentiation] GO:0045687 [positive regulation of glial cell differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045833 [negative regulation of lipid metabolic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046330 [positive regulation of JNK cascade] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046827 [positive regulation of protein export from nucleus] GO:0048711 [positive regulation of astrocyte differentiation] GO:0050766 [positive regulation of phagocytosis] GO:0050768 [negative regulation of neurogenesis] GO:0050796 [regulation of insulin secretion] GO:0050900 [leukocyte migration] GO:0050995 [negative regulation of lipid catabolic process] GO:0050996 [positive regulation of lipid catabolic process] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051384 [response to glucocorticoid] GO:0060355 [positive regulation of cell adhesion molecule production] GO:0060559 [positive regulation of calcidiol 1-monooxygenase activity] GO:0070062 [extracellular exosome] GO:0070164 [negative regulation of adiponectin secretion] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:0071222 [cellular response to lipopolysaccharide] GO:0071236 [cellular response to antibiotic] GO:0071260 [cellular response to mechanical stimulus] GO:0071310 [cellular response to organic substance] GO:0071333 [cellular response to glucose stimulus] GO:0071396 [cellular response to lipid] GO:0071398 [cellular response to fatty acid] GO:0071407 [cellular response to organic cyclic compound] GO:0071414 [cellular response to methotrexate] GO:0071548 [response to dexamethasone] GO:0071639 [positive regulation of monocyte chemotactic protein-1 production] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1903140 [regulation of establishment of endothelial barrier] GO:2000173 [negative regulation of branching morphogenesis of a nerve] GO:2000178 [negative regulation of neural precursor cell proliferation] GO:2000778 [positive regulation of interleukin-6 secretion] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]