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POLR1B

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GENERAL INFORMATION

Gene name

 POLR1B

Gene description

 Polymerase (RNA) I polypeptide B, 128kDa

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (supported), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA037528
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli & cytosol.

Main location

 Nucleoli (supported), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA037528 A-431 Nucleoli
Cytosol
HPA037528 U-2 OS No staining    
HPA037528 U-251 MG Nucleoli
Cytosol

GENE INFORMATION

Gene name

 POLR1B (HGNC Symbol)

Synonyms

 FLJ10816, FLJ21921, RPA2, Rpo1-2

Description

 Polymerase (RNA) I polypeptide B, 128kDa (HGNC Symbol)

Entrez gene summary

 Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 112541915 - 112577150

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125630 (version 83.38)

Entrez gene

 84172

UniProt

 Q9H9Y6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H9Y6

Antibodypedia

 POLR1B antibodies

PROTEIN BROWSER
POLR1B-001
POLR1B-003
POLR1B-005
POLR1B-006
POLR1B-007
POLR1B-015
POLR1B-201
POLR1B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR1B-001
ENSP00000263331
ENST00000263331
Q9H9Y6 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA2
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0032549 [ribonucleoside binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
Show all
 1135 aa
128.2 kDa 		No 0
POLR1B-003
ENSP00000387143
ENST00000409894
Q9H9Y6 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA2
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0032549 [ribonucleoside binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
Show all
 952 aa
107.9 kDa 		No 0
POLR1B-005
ENSP00000405358
ENST00000417433
Q9H9Y6 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA2
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0032549 [ribonucleoside binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
Show all
 1079 aa
122 kDa 		No 0
POLR1B-006
ENSP00000415754
ENST00000430769
C9JJG2 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0032549 [ribonucleoside binding]
Show all
 114 aa
12.7 kDa 		No 0
POLR1B-007
ENSP00000388577
ENST00000438748
C9JS83 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0032549 [ribonucleoside binding]
Show all
 128 aa
14.1 kDa 		No 0
POLR1B-015
ENSP00000394408
ENST00000458012
H7C0D9 [Direct mapping]
DNA-directed RNA polymerase
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0032549 [ribonucleoside binding]
Show all
 308 aa
34.4 kDa 		No 0
POLR1B-201
ENSP00000437914
ENST00000537335
Q9H9Y6 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA2
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0032549 [ribonucleoside binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
Show all
 924 aa
104.5 kDa 		No 0
POLR1B-202
ENSP00000444136
ENST00000541869
Q9H9Y6 [Direct mapping]
DNA-directed RNA polymerase I subunit RPA2
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0007566 [embryo implantation]
GO:0009303 [rRNA transcription]
GO:0010467 [gene expression]
GO:0017126 [nucleologenesis]
GO:0032549 [ribonucleoside binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
Show all
 1173 aa
132.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.