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CLPP

GENERAL INFORMATION

Gene name

 CLPP

Gene description

 Caseinolytic mitochondrial matrix peptidase proteolytic subunit

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA010649
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010649

GENE INFORMATION

Gene name

 CLPP

Synonyms

Description

 Caseinolytic mitochondrial matrix peptidase proteolytic subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6361452 - 6368908

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125656 (version 83.38)

Entrez gene

 8192

UniProt

 Q16740 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16740

Antibodypedia

 CLPP antibodies

PROTEIN BROWSER
CLPP-001
CLPP-004
CLPP-005
CLPP-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLPP-001
ENSP00000245816
ENST00000245816
Q16740 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit, mitochondrial
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0009368 [endopeptidase Clp complex]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
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 277 aa
30.2 kDa 		No 0
CLPP-004
ENSP00000469124
ENST00000596605
M0QXE9 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit, mitochondrial
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 56 aa
6.1 kDa 		No 0
CLPP-005
ENSP00000472227
ENST00000596149
M0R208 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
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 190 aa
20.6 kDa 		No 0
CLPP-006
ENSP00000470098
ENST00000597326
M0QYV5 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
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 160 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.