Fields »
ABOUT
HELP
BLOG
CLPP

GENERAL INFORMATION

Gene name

 CLPP

Gene description

 Caseinolytic mitochondrial matrix peptidase proteolytic subunit

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA010649
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CLPP

Synonyms

Description

 Caseinolytic mitochondrial matrix peptidase proteolytic subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6361452 - 6368908

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125656 (version 83.38)

Entrez gene

 8192

UniProt

 Q16740 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16740

Antibodypedia

 CLPP antibodies

PROTEIN BROWSER
CLPP-001
CLPP-004
CLPP-005
CLPP-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLPP-001
ENSP00000245816
ENST00000245816
Q16740 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0009368 [endopeptidase Clp complex]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 277 aa
30.2 kDa 		No 0
CLPP-004
ENSP00000469124
ENST00000596605
M0QXE9 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 56 aa
6.1 kDa 		No 0
CLPP-005
ENSP00000472227
ENST00000596149
M0R208 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
Show all
 190 aa
20.6 kDa 		No 0
CLPP-006
ENSP00000470098
ENST00000597326
M0QYV5 [Direct mapping]
ATP-dependent Clp protease proteolytic subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 160 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.