Cell atlas - RTN2 - The Human Protein Atlas

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RTN2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RTN2
Gene description	Reticulon 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA034941
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034941	A-431	Nuclear speckles
	HPA034941	U-2 OS	Nuclear speckles
	HPA034941	U-251 MG	Nuclear speckles
	HPA034941	U-251 MG	Cytosol

GENE INFORMATION
Gene name	RTN2 (HGNC Symbol)
Synonyms	NSP2, NSPL1, SPG12
Description	Reticulon 2 (HGNC Symbol)
Entrez gene summary	This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	45485289 - 45497061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125744 (version 83.38)
Entrez gene	6253
UniProt	O75298 (UniProt - Evidence at protein level)
neXtProt	NX_O75298
Antibodypedia	RTN2 antibodies

PROTEIN BROWSER

RTN2-001	RTN2-003	RTN2-005	RTN2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTN2-001 ENSP00000245923 ENST00000245923	O75298 [Direct mapping] Reticulon-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0012505 [endomembrane system] GO:0014802 [terminal cisterna] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030315 [T-tubule] GO:0046324 [regulation of glucose import] GO:0065002 [intracellular protein transmembrane transport] Show all	545 aa 59.3 kDa	No	2
RTN2-003 ENSP00000345127 ENST00000344680	O75298 [Direct mapping] Reticulon-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0012505 [endomembrane system] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	472 aa 51.4 kDa	No	2
RTN2-005 ENSP00000466619 ENST00000590526	K7EMR7 [Direct mapping] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] Show all	271 aa 29.5 kDa	No	2
RTN2-006 ENSP00000398178 ENST00000430715	O75298 [Direct mapping] Reticulon-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0012505 [endomembrane system] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	205 aa 22.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.