Expression of RTN2 in cancer - Summary - The Human Protein Atlas

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RTN2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RTN2
Gene description	Reticulon 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in muscle cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA034948
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034948

GENE INFORMATION
Gene name	RTN2 (HGNC Symbol)
Synonyms	NSP2, NSPL1, SPG12
Description	Reticulon 2 (HGNC Symbol)
Entrez gene summary	This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	45485289 - 45497061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125744 (version 83.38)
Entrez gene	6253
UniProt	O75298 (UniProt - Evidence at protein level)
neXtProt	NX_O75298
Antibodypedia	RTN2 antibodies

PROTEIN BROWSER

RTN2-001	RTN2-003	RTN2-005	RTN2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTN2-001 ENSP00000245923 ENST00000245923	O75298 [Direct mapping] Reticulon-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0012505 [endomembrane system] GO:0014802 [terminal cisterna] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030315 [T-tubule] GO:0046324 [regulation of glucose import] GO:0065002 [intracellular protein transmembrane transport] Show all	545 aa 59.3 kDa	No	2
RTN2-003 ENSP00000345127 ENST00000344680	O75298 [Direct mapping] Reticulon-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0012505 [endomembrane system] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	472 aa 51.4 kDa	No	2
RTN2-005 ENSP00000466619 ENST00000590526	K7EMR7 [Direct mapping] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] Show all	271 aa 29.5 kDa	No	2
RTN2-006 ENSP00000398178 ENST00000430715	O75298 [Direct mapping] Reticulon-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0012505 [endomembrane system] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	205 aa 22.3 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.