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PAX1

GENERAL INFORMATION

Gene name

 PAX1

Gene description

 Paired box 1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (head and neck cancer)
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (head and neck cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PAX1

Synonyms

Description

 Paired box 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012]

Chromosome

 20

Cytoband

 p11.22

Chromosome location (bp)

 21705659 - 21718486

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125813 (version 83.38)

Entrez gene

 5075

UniProt

 P15863 (UniProt - Evidence at protein level)

neXtProt

 NX_P15863

Antibodypedia

 PAX1 antibodies

PROTEIN BROWSER
PAX1-001
PAX1-002
PAX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAX1-001
ENSP00000381499
ENST00000398485
P15863 [Direct mapping]
Paired box protein Pax-1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
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GO:0001501 [skeletal system development]
GO:0001756 [somitogenesis]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007389 [pattern specification process]
GO:0008283 [cell proliferation]
GO:0043367 [CD4-positive, alpha-beta T cell differentiation]
GO:0043374 [CD8-positive, alpha-beta T cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048538 [thymus development]
GO:0060017 [parathyroid gland development]
GO:0060349 [bone morphogenesis]
GO:0061056 [sclerotome development]
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 534 aa
55.5 kDa 		No 0
PAX1-002
ENSP00000410355
ENST00000444366
P15863 [Direct mapping]
Paired box protein Pax-1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
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 433 aa
45.1 kDa 		No 0
PAX1-201
ENSP00000481334
ENST00000613128
A0A087WXV5 [Direct mapping]
Paired box protein Pax-1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
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 457 aa
47.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.