Tissue expression of PAX1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PAX1
Gene description	Paired box 1
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (parathyroid gland)
GTEx:	Tissue enhanced (thyroid gland)
FANTOM5:	Tissue enriched (tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (tonsil)

GENE INFORMATION
Gene name	PAX1
Synonyms
Description	Paired box 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012]
Chromosome	20
Cytoband	p11.22
Chromosome location (bp)	21705659 - 21718486
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125813 (version 83.38)
Entrez gene	5075
UniProt	P15863 (UniProt - Evidence at protein level)
neXtProt	NX_P15863
Antibodypedia	PAX1 antibodies

PROTEIN BROWSER

PAX1-001	PAX1-002	PAX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAX1-001 ENSP00000381499 ENST00000398485	P15863 [Direct mapping] Paired box protein Pax-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0001501 [skeletal system development] GO:0001756 [somitogenesis] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007389 [pattern specification process] GO:0008283 [cell proliferation] GO:0043367 [CD4-positive, alpha-beta T cell differentiation] GO:0043374 [CD8-positive, alpha-beta T cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048538 [thymus development] GO:0060017 [parathyroid gland development] GO:0060349 [bone morphogenesis] GO:0061056 [sclerotome development] Show all	534 aa 55.5 kDa	No	0
PAX1-002 ENSP00000410355 ENST00000444366	P15863 [Direct mapping] Paired box protein Pax-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0001501 [skeletal system development] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] Show all	433 aa 45.1 kDa	No	0
PAX1-201 ENSP00000481334 ENST00000613128	A0A087WXV5 [Direct mapping] Paired box protein Pax-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] Show all	457 aa 47.2 kDa	No	0