Fields »
ABOUT
HELP
BLOG
AP5S1

GENERAL INFORMATION

Gene name

 AP5S1

Gene description

 Adaptor-related protein complex 5, sigma 1 subunit

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA048244 , CAB034200
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048244
CAB034200

GENE INFORMATION

Gene name

 AP5S1 (HGNC Symbol)

Synonyms

 C20orf29, FLJ11168

Description

 Adaptor-related protein complex 5, sigma 1 subunit (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3820524 - 3828837

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125843 (version 83.38)

Entrez gene

 55317

UniProt

 Q9NUS5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NUS5

Antibodypedia

 AP5S1 antibodies

PROTEIN BROWSER
AP5S1-001
AP5S1-002
AP5S1-003
AP5S1-004
AP5S1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP5S1-001
ENSP00000481750
ENST00000615891
Q9NUS5 [Direct mapping]
AP-5 complex subunit sigma-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0015031 [protein transport]
GO:0016197 [endosomal transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0031902 [late endosome membrane]
Show all
 200 aa
22.5 kDa 		No 1
AP5S1-002
ENSP00000405487
ENST00000455742
A2A2L4 [Direct mapping]
AP-5 complex subunit sigma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016197 [endosomal transport]
GO:0030119 [AP-type membrane coat adaptor complex]
Show all
 86 aa
9.7 kDa 		No 0
AP5S1-003
ENSP00000368892
ENST00000379573
Q5JX74 [Direct mapping]
AP-5 complex subunit sigma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0016197 [endosomal transport]
GO:0030119 [AP-type membrane coat adaptor complex]
Show all
 59 aa
6.7 kDa 		No 0
AP5S1-004
ENSP00000368886
ENST00000379567
Q9NUS5 [Direct mapping]
AP-5 complex subunit sigma-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0015031 [protein transport]
GO:0016197 [endosomal transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0031902 [late endosome membrane]
Show all
 200 aa
22.5 kDa 		No 1
AP5S1-201
ENSP00000246041
ENST00000246041
Q9NUS5 [Direct mapping]
AP-5 complex subunit sigma-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0015031 [protein transport]
GO:0016197 [endosomal transport]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0031902 [late endosome membrane]
Show all
 200 aa
22.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.