Cell atlas - S1PR4 - The Human Protein Atlas

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S1PR4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	S1PR4
Gene description	Sphingosine-1-phosphate receptor 4
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enhanced (REH, HL-60, U-937, HDLM-2, NB-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA060601 , HPA067232
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, HL-60, U-937, HDLM-2, NB-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA060601	NB-4	Mitochondria
	HPA060601	REH	Mitochondria
	HPA060601	U-2 OS	Mitochondria
	HPA067232	NB-4	Mitochondria
	HPA067232	REH	No staining
	HPA067232	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	S1PR4 (HGNC Symbol)
Synonyms	EDG6
Description	Sphingosine-1-phosphate receptor 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	3172346 - 3180332
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125910 (version 83.38)
Entrez gene	8698
UniProt	O95977 (UniProt - Evidence at protein level)
neXtProt	NX_O95977
Antibodypedia	S1PR4 antibodies

PROTEIN BROWSER

S1PR4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
S1PR4-001 ENSP00000246115 ENST00000246115	O95977 [Direct mapping] Sphingosine 1-phosphate receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0038036 [sphingosine-1-phosphate receptor activity] Show all	384 aa 41.6 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.