Expression of MAX in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MAX
Gene description	MYC associated factor X
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression at variable levels in most tissues. Also expressed in dendrites in the brain.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA003474 , CAB000328
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and renal cancer (unfavourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA003474	CAB000328

GENE INFORMATION
Gene name	MAX (HGNC Symbol)
Synonyms	bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8
Description	MYC associated factor X (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	14
Cytoband	q23.3
Chromosome location (bp)	65006174 - 65102695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125952 (version 83.38)
Entrez gene	4149
UniProt	P61244 (UniProt - Evidence at protein level)
neXtProt	NX_P61244
Antibodypedia	MAX antibodies

PROTEIN BROWSER

MAX-001	MAX-002	MAX-003	MAX-004	MAX-005	MAX-006	MAX-010	MAX-011	MAX-012	MAX-013	MAX-014	MAX-017	MAX-018	MAX-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAX-001 ENSP00000351175 ENST00000358402	P61244 [Direct mapping] Protein max Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030425 [dendrite] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	151 aa 17.2 kDa	No	0
MAX-002 ENSP00000351490 ENST00000358664	P61244 [Direct mapping] Protein max Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006461 [protein complex assembly] GO:0009267 [cellular response to starvation] GO:0010243 [response to organonitrogen compound] GO:0010629 [negative regulation of gene expression] GO:0016605 [PML body] GO:0030425 [dendrite] GO:0032403 [protein complex binding] GO:0032868 [response to insulin] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048678 [response to axon injury] GO:0051402 [neuron apoptotic process] GO:0060041 [retina development in camera-type eye] GO:0071339 [MLL1 complex] GO:0071375 [cellular response to peptide hormone stimulus] Show all	160 aa 18.3 kDa	No	0
MAX-003 ENSP00000342482 ENST00000341653	P61244 [Direct mapping] Protein max Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030425 [dendrite] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	83 aa 9.6 kDa	No	0
MAX-004 ENSP00000284165 ENST00000284165	P61244 [Direct mapping] Protein max Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030425 [dendrite] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	134 aa 15.4 kDa	No	0
MAX-005 ENSP00000246163 ENST00000246163	P61244 [Direct mapping] Protein max Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030425 [dendrite] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	96 aa 11.5 kDa	No	0
MAX-006 ENSP00000452378 ENST00000556979	P61244 [Direct mapping] Protein max A0A024R682 [Target identity:100%; Query identity:100%] MYC associated factor X, isoform CRA_d Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030425 [dendrite] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	103 aa 12.1 kDa	No	0
MAX-010 ENSP00000452286 ENST00000555667	Q6V3B1 [Direct mapping] MAX protein; Protein max Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046983 [protein dimerization activity] Show all	94 aa 11 kDa	No	0
MAX-011 ENSP00000450763 ENST00000555932	G3V2N4 [Direct mapping] Protein max Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		82 aa 8.7 kDa	No	0
MAX-012 ENSP00000452405 ENST00000555419	G3V5L1 [Direct mapping] Protein max Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046983 [protein dimerization activity] Show all	124 aa 14.1 kDa	No	0
MAX-013 ENSP00000452197 ENST00000557746	G3V563 [Direct mapping] Protein max Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046983 [protein dimerization activity] Show all	121 aa 14 kDa	No	0
MAX-014 ENSP00000450818 ENST00000556443	G3V2R5 [Direct mapping] Protein max Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046983 [protein dimerization activity] Show all	125 aa 14.3 kDa	No	0
MAX-017 ENSP00000452206 ENST00000556892	G3V570 [Direct mapping] Protein max Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.2 kDa	No	0
MAX-018 ENSP00000450955 ENST00000557277	G3V302 [Direct mapping] Protein max Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10.7 kDa	No	0
MAX-201 ENSP00000480127 ENST00000618858	P61244 [Direct mapping] Protein max A0A024R682 [Target identity:100%; Query identity:100%] MYC associated factor X, isoform CRA_d Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030425 [dendrite] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	103 aa 12.1 kDa	No	0