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HECTD3

GENERAL INFORMATION

Gene name

 HECTD3

Gene description

 HECT domain containing E3 ubiquitin protein ligase 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA027467
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and liver cancer (unfavourable).
Thyroid cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027467

GENE INFORMATION

Gene name

 HECTD3 (HGNC Symbol)

Synonyms

 FLJ21156

Description

 HECT domain containing E3 ubiquitin protein ligase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 45002540 - 45011329

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126107 (version 83.38)

Entrez gene

 79654

UniProt

 Q5T447 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5T447

Antibodypedia

 HECTD3 antibodies

PROTEIN BROWSER
HECTD3-001
HECTD3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HECTD3-001
ENSP00000361245
ENST00000372172
Q5T447 [Direct mapping]
E3 ubiquitin-protein ligase HECTD3
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019905 [syntaxin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061630 [ubiquitin protein ligase activity]
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 861 aa
97.1 kDa 		No 0
HECTD3-002
ENSP00000361241
ENST00000372168
Q5T447 [Direct mapping]
E3 ubiquitin-protein ligase HECTD3
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061630 [ubiquitin protein ligase activity]
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 471 aa
53.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.