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HECT domain containing E3 ubiquitin protein ligase 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019905 [syntaxin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0061630 [ubiquitin protein ligase activity]
