We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
CCR7
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CCR7

Gene description

Chemokine (C-C motif) receptor 7

Protein class

Cancer-related genes
CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (appendix, lymph node, spleen, tonsil)
GTEx:Group enriched (small intestine, spleen)
FANTOM5:Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in subsets of inflammatory cells

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB003796
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, lymph node, spleen, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, lymph node, spleen, tonsil)

GENE INFORMATION

Gene name

CCR7 (HGNC Symbol)

Synonyms

BLR2, CD197, CDw197, CMKBR7, EBI1

Description

Chemokine (C-C motif) receptor 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

40553769 - 40565472

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126353 (version 83.38)

Entrez gene

1236

UniProt

P32248 (UniProt - Evidence at transcript level)

neXtProt

NX_P32248

Antibodypedia

CCR7 antibodies

PROTEIN BROWSER

CCR7-001
CCR7-002
CCR7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR7-001
ENSP00000246657
ENST00000246657
P32248 [Direct mapping]
C-C chemokine receptor type 7
A0N0Q0 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 7; cDNA FLJ45911 fis, clone PEBLM2005615, highly similar to C-C chemokine receptor type 7
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001768 [establishment of T cell polarity]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002407 [dendritic cell chemotaxis]
GO:0002408 [myeloid dendritic cell chemotaxis]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0002885 [positive regulation of hypersensitivity]
GO:0002922 [positive regulation of humoral immune response]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031529 [ruffle organization]
GO:0032496 [response to lipopolysaccharide]
GO:0032649 [regulation of interferon-gamma production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0034695 [response to prostaglandin E]
GO:0035757 [chemokine (C-C motif) ligand 19 binding]
GO:0035758 [chemokine (C-C motif) ligand 21 binding]
GO:0038115 [chemokine (C-C motif) ligand 19 signaling pathway]
GO:0038116 [chemokine (C-C motif) ligand 21 signaling pathway]
GO:0038117 [C-C motif chemokine 19 receptor activity]
GO:0038121 [C-C motif chemokine 21 receptor activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045060 [negative thymic T cell selection]
GO:0045785 [positive regulation of cell adhesion]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0048872 [homeostasis of number of cells]
GO:0050706 [regulation of interleukin-1 beta secretion]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071731 [response to nitric oxide]
GO:0072610 [interleukin-12 secretion]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090630 [activation of GTPase activity]
GO:0097022 [lymphocyte migration into lymph node]
GO:0097029 [mature conventional dendritic cell differentiation]
GO:2000107 [negative regulation of leukocyte apoptotic process]
GO:2000147 [positive regulation of cell motility]
GO:2000510 [positive regulation of dendritic cell chemotaxis]
GO:2000522 [positive regulation of immunological synapse formation]
GO:2000525 [positive regulation of T cell costimulation]
GO:2000526 [positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation]
GO:2000547 [regulation of dendritic cell dendrite assembly]
Show all
378 aa
42.9 kDa
Yes 7
CCR7-002
ENSP00000462631
ENST00000579344
J3KSS9 [Direct mapping]
C-C chemokine receptor type 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
372 aa
42.2 kDa
Yes 7
CCR7-003
ENSP00000463075
ENST00000578085
J3KTN5 [Direct mapping]
C-C chemokine receptor type 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
199 aa
22.6 kDa
No 5

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.