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PRDX5

GENERAL INFORMATION

Gene name

 PRDX5

Gene description

 Peroxiredoxin 5

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, highly abundant in most glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA037915 , HPA037916 , CAB008661
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037915
HPA037916
CAB008661

GENE INFORMATION

Gene name

 PRDX5 (HGNC Symbol)

Synonyms

 ACR1, AOEB166, B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10

Description

 Peroxiredoxin 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64318088 - 64321811

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126432 (version 83.38)

Entrez gene

 25824

UniProt

 P30044 (UniProt - Evidence at protein level)

neXtProt

 NX_P30044

Antibodypedia

 PRDX5 antibodies

PROTEIN BROWSER
PRDX5-001
PRDX5-002
PRDX5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDX5-001
ENSP00000265462
ENST00000265462
P30044 [Direct mapping]
Peroxiredoxin-5, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001016 [RNA polymerase III regulatory region DNA binding]
GO:0004601 [peroxidase activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0010467 [gene expression]
GO:0016209 [antioxidant activity]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0016491 [oxidoreductase activity]
GO:0031410 [cytoplasmic vesicle]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046983 [protein dimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051354 [negative regulation of oxidoreductase activity]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0060785 [regulation of apoptosis involved in tissue homeostasis]
GO:0070062 [extracellular exosome]
GO:0070995 [NADPH oxidation]
GO:0072541 [peroxynitrite reductase activity]
GO:2001057 [reactive nitrogen species metabolic process]
Show all
 214 aa
22.1 kDa 		No 0
PRDX5-002
ENSP00000335334
ENST00000352435
P30044 [Direct mapping]
Peroxiredoxin-5, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001016 [RNA polymerase III regulatory region DNA binding]
GO:0004601 [peroxidase activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0010467 [gene expression]
GO:0016209 [antioxidant activity]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0016491 [oxidoreductase activity]
GO:0031410 [cytoplasmic vesicle]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046983 [protein dimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051354 [negative regulation of oxidoreductase activity]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0060785 [regulation of apoptosis involved in tissue homeostasis]
GO:0070062 [extracellular exosome]
GO:0070995 [NADPH oxidation]
GO:0072541 [peroxynitrite reductase activity]
GO:2001057 [reactive nitrogen species metabolic process]
Show all
 170 aa
17.5 kDa 		No 0
PRDX5-003
ENSP00000335363
ENST00000347941
P30044 [Direct mapping]
Peroxiredoxin-5, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001016 [RNA polymerase III regulatory region DNA binding]
GO:0004601 [peroxidase activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0010467 [gene expression]
GO:0016209 [antioxidant activity]
GO:0016480 [negative regulation of transcription from RNA polymerase III promoter]
GO:0016491 [oxidoreductase activity]
GO:0031410 [cytoplasmic vesicle]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046983 [protein dimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051354 [negative regulation of oxidoreductase activity]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0060785 [regulation of apoptosis involved in tissue homeostasis]
GO:0070062 [extracellular exosome]
GO:0070995 [NADPH oxidation]
GO:0072541 [peroxynitrite reductase activity]
GO:2001057 [reactive nitrogen species metabolic process]
Show all
 125 aa
12.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.