Expression of ASL in cancer - Summary - The Human Protein Atlas

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ASL

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASL
Gene description	Argininosuccinate lyase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in hepatocytes and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA016646 , CAB003696
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016646	CAB003696

GENE INFORMATION
Gene name	ASL
Synonyms
Description	Argininosuccinate lyase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q11.21
Chromosome location (bp)	66075798 - 66093558
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126522 (version 83.38)
Entrez gene	435
UniProt	P04424 (UniProt - Evidence at protein level)
neXtProt	NX_P04424
Antibodypedia	ASL antibodies

PROTEIN BROWSER

ASL-001	ASL-004	ASL-005	ASL-006	ASL-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASL-001 ENSP00000307188 ENST00000304874	P04424 [Direct mapping] Argininosuccinate lyase A0A024RDL8 [Target identity:100%; Query identity:100%] Argininosuccinate lyase, isoform CRA_b Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000050 [urea cycle] GO:0003824 [catalytic activity] GO:0004056 [argininosuccinate lyase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006475 [internal protein amino acid acetylation] GO:0006526 [arginine biosynthetic process] GO:0006527 [arginine catabolic process] GO:0006595 [polyamine metabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042450 [arginine biosynthetic process via ornithine] GO:0044281 [small molecule metabolic process] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] Show all	464 aa 51.7 kDa	No	0
ASL-004 ENSP00000370219 ENST00000380839	P04424 [Direct mapping] Argininosuccinate lyase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000050 [urea cycle] GO:0003824 [catalytic activity] GO:0004056 [argininosuccinate lyase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006475 [internal protein amino acid acetylation] GO:0006526 [arginine biosynthetic process] GO:0006527 [arginine catabolic process] GO:0006595 [polyamine metabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042450 [arginine biosynthetic process via ornithine] GO:0044281 [small molecule metabolic process] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] Show all	438 aa 48.7 kDa	No	0
ASL-005 ENSP00000378741 ENST00000395332	P04424 [Direct mapping] Argininosuccinate lyase A0A024RDL8 [Target identity:100%; Query identity:100%] Argininosuccinate lyase, isoform CRA_b Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000050 [urea cycle] GO:0003824 [catalytic activity] GO:0004056 [argininosuccinate lyase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006475 [internal protein amino acid acetylation] GO:0006526 [arginine biosynthetic process] GO:0006527 [arginine catabolic process] GO:0006595 [polyamine metabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042450 [arginine biosynthetic process via ornithine] GO:0044281 [small molecule metabolic process] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] Show all	464 aa 51.7 kDa	No	0
ASL-006 ENSP00000378740 ENST00000395331	P04424 [Direct mapping] Argininosuccinate lyase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000050 [urea cycle] GO:0003824 [catalytic activity] GO:0004056 [argininosuccinate lyase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006475 [internal protein amino acid acetylation] GO:0006526 [arginine biosynthetic process] GO:0006527 [arginine catabolic process] GO:0006595 [polyamine metabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042450 [arginine biosynthetic process via ornithine] GO:0044281 [small molecule metabolic process] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] Show all	444 aa 49.5 kDa	No	0
ASL-007 ENSP00000354710 ENST00000362000	F8W943 [Direct mapping] Argininosuccinate lyase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004056 [argininosuccinate lyase activity] GO:0042450 [arginine biosynthetic process via ornithine] Show all	242 aa 27.4 kDa	No	0

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