Expression of AHDC1 in cancer - Summary - The Human Protein Atlas

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AHDC1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AHDC1
Gene description	AT hook, DNA binding motif, containing 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA028648 , HPA028691
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), head and neck cancer (favourable) and ovarian cancer (unfavourable).
Endometrial cancer p<0.001 Head and neck cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028648	HPA028691

GENE INFORMATION
Gene name	AHDC1 (HGNC Symbol)
Synonyms	DJ159A19.3, RP1-159A19.1
Description	AT hook, DNA binding motif, containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing two AT-hooks, which likely function in DNA binding. Mutations in this gene were found in individuals with Xia-Gibbs syndrome. [provided by RefSeq, Jun 2014]
Chromosome	1
Cytoband
Chromosome location (bp)	27534035 - 27604431
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126705 (version 83.38)
Entrez gene	27245
UniProt	Q5TGY3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TGY3
Antibodypedia	AHDC1 antibodies

PROTEIN BROWSER

AHDC1-001	AHDC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AHDC1-001 ENSP00000247087 ENST00000247087	Q5TGY3 [Direct mapping] AT-hook DNA-binding motif-containing protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	1603 aa 168.3 kDa	No	0
AHDC1-201 ENSP00000363123 ENST00000374011	Q5TGY3 [Direct mapping] AT-hook DNA-binding motif-containing protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	1603 aa 168.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.