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SSX1

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GENERAL INFORMATION

Gene name

 SSX1

Gene description

 Synovial sarcoma, X breakpoint 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Group enriched (Karpas-707, Daudi, U-2197)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Nucleoli (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA045683
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Karpas-707, Daudi, U-2197)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleus (approved), Nucleoli (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045683 PC-3 Nucleus Intensity
Nucleoli Intensity
HPA045683 RH-30 Nucleus Intensity
Nucleoli Intensity
HPA045683 U-2 OS Nucleus Intensity
Nucleoli Intensity

GENE INFORMATION

Gene name

 SSX1 (HGNC Symbol)

Synonyms

 CT5.1

Description

 Synovial sarcoma, X breakpoint 1 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48255317 - 48267444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126752 (version 83.38)

Entrez gene

 6756

UniProt

 Q16384 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16384

Antibodypedia

 SSX1 antibodies

PROTEIN BROWSER
SSX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSX1-001
ENSP00000366118
ENST00000376919
Q16384 [Direct mapping]
Protein SSX1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 188 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.