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SSX1

GENERAL INFORMATION

Gene name

 SSX1

Gene description

 Synovial sarcoma, X breakpoint 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Group enriched (Daudi, Karpas-707, U-2197)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA045683
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045683

GENE INFORMATION

Gene name

 SSX1 (HGNC Symbol)

Synonyms

 CT5.1

Description

 Synovial sarcoma, X breakpoint 1 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48255317 - 48267444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126752 (version 83.38)

Entrez gene

 6756

UniProt

 Q16384 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16384

Antibodypedia

 SSX1 antibodies

PROTEIN BROWSER
SSX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSX1-001
ENSP00000366118
ENST00000376919
Q16384 [Direct mapping]
Protein SSX1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 188 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.