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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HSPA2
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HSPA2

Gene description

Heat shock 70kDa protein 2

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, BEWO, BJ hTERT+, SCLC-21H)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression of varying intensity in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

Approved based on 2 antibodies.
HPA000798 , HPA052504
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PROGNOSTIC SUMMARY

Prognostic marker in breast cancer (favourable) and lung cancer (unfavourable).
Breast cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA000798
HPA052504

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most tumours showed moderate to strong nuclear staining. Malignant lymphomas were weaker stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of breast, ovarian and endometrial cancers showed moderate nuclear and cytoplasmic staining. Several cases of gliomas, melanomas, skin, liver, lung, stomach, urothelial and cervix cancers along with head and neck cancers displayed moderate nuclear positivity. Remaining cancer tissues were mainly negative.

GENE INFORMATION

Gene name

HSPA2

Synonyms

Description

Heat shock 70kDa protein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

14

Cytoband

q23.3

Chromosome location (bp)

64535905 - 64546173

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126803 (version 83.38)

Entrez gene

3306

UniProt

P54652 (UniProt - Evidence at protein level)

neXtProt

NX_P54652

Antibodypedia

HSPA2 antibodies

PROTEIN BROWSER

HSPA2-001
HSPA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSPA2-001
ENSP00000378199
ENST00000394709
P54652 [Direct mapping]
Heat shock-related 70 kDa protein 2
A0A024R6B5 [Target identity:100%; Query identity:100%]
Heat shock 70kDa protein 2, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000795 [synaptonemal complex]
GO:0001673 [male germ cell nucleus]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006986 [response to unfolded protein]
GO:0007140 [male meiosis]
GO:0007141 [male meiosis I]
GO:0007286 [spermatid development]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0031662 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle]
GO:0032781 [positive regulation of ATPase activity]
GO:0036128 [CatSper complex]
GO:0042026 [protein refolding]
GO:0043209 [myelin sheath]
GO:0051082 [unfolded protein binding]
GO:0051861 [glycolipid binding]
GO:0070062 [extracellular exosome]
GO:0070194 [synaptonemal complex disassembly]
GO:0072562 [blood microparticle]
GO:0090084 [negative regulation of inclusion body assembly]
GO:1901896 [positive regulation of calcium-transporting ATPase activity]
Show all
639 aa
70 kDa
No 0
HSPA2-201
ENSP00000247207
ENST00000247207
P54652 [Direct mapping]
Heat shock-related 70 kDa protein 2
A0A024R6B5 [Target identity:100%; Query identity:100%]
Heat shock 70kDa protein 2, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006986 [response to unfolded protein]
GO:0007140 [male meiosis]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0036128 [CatSper complex]
GO:0042026 [protein refolding]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:0090084 [negative regulation of inclusion body assembly]
Show all
639 aa
70 kDa
No 0

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