Fields »
ABOUT
HELP
BLOG
AVPR2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 AVPR2

Gene description

 Arginine vasopressin receptor 2

Protein class

 Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SCLC-21H, EFO-21, U-698)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, EFO-21, U-698)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 AVPR2 (HGNC Symbol)

Synonyms

 DIR, DIR3, V2R

Description

 Arginine vasopressin receptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153902531 - 153907166

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126895 (version 83.38)

Entrez gene

 554

UniProt

 P30518 (UniProt - Evidence at protein level)

neXtProt

 NX_P30518

Antibodypedia

 AVPR2 antibodies

PROTEIN BROWSER
AVPR2-001
AVPR2-003
AVPR2-004
AVPR2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AVPR2-001
ENSP00000351805
ENST00000358927
P30518 [Direct mapping]
Vasopressin V2 receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0003084 [positive regulation of systemic arterial blood pressure]
GO:0003091 [renal water homeostasis]
GO:0004930 [G-protein coupled receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006833 [water transport]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007588 [excretion]
GO:0007599 [hemostasis]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0021537 [telencephalon development]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032609 [interferon-gamma production]
GO:0032870 [cellular response to hormone stimulus]
GO:0034097 [response to cytokine]
GO:0035811 [negative regulation of urine volume]
GO:0035814 [negative regulation of renal sodium excretion]
GO:0042277 [peptide binding]
GO:0045777 [positive regulation of blood pressure]
GO:0045907 [positive regulation of vasoconstriction]
GO:0055085 [transmembrane transport]
GO:1901652 [response to peptide]
Show all
 371 aa
40.3 kDa 		No 7
AVPR2-003
ENSP00000359066
ENST00000370049
P30518 [Direct mapping]
Vasopressin V2 receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0003091 [renal water homeostasis]
GO:0004930 [G-protein coupled receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006833 [water transport]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007588 [excretion]
GO:0007599 [hemostasis]
GO:0010628 [positive regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032870 [cellular response to hormone stimulus]
GO:0042277 [peptide binding]
GO:0045907 [positive regulation of vasoconstriction]
GO:0055085 [transmembrane transport]
GO:1901652 [response to peptide]
Show all
 309 aa
33.7 kDa 		No 6
AVPR2-004
ENSP00000393513
ENST00000430697
C9JV81 [Direct mapping]
Vasopressin V2 receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0004930 [G-protein coupled receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0032870 [cellular response to hormone stimulus]
GO:0042277 [peptide binding]
GO:0045907 [positive regulation of vasoconstriction]
GO:1901652 [response to peptide]
Show all
 372 aa
39.9 kDa 		No 6
AVPR2-201
ENSP00000338072
ENST00000337474
P30518 [Direct mapping]
Vasopressin V2 receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0003091 [renal water homeostasis]
GO:0004930 [G-protein coupled receptor activity]
GO:0005000 [vasopressin receptor activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006833 [water transport]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007588 [excretion]
GO:0007599 [hemostasis]
GO:0010628 [positive regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032870 [cellular response to hormone stimulus]
GO:0042277 [peptide binding]
GO:0045907 [positive regulation of vasoconstriction]
GO:0055085 [transmembrane transport]
GO:1901652 [response to peptide]
Show all
 371 aa
40.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.