Expression of AVPR2 in cancer - Summary

GENERAL INFORMATION
Gene name	AVPR2
Gene description	Arginine vasopressin receptor 2
Protein class	Disease related genes FDA approved drug targets G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (EFO-21, SCLC-21H, U-698)
HPA (normal tissue):	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression mainly in renal tubules, adipocytes and smooth muscle cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA046678
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA046678

GENE INFORMATION
Gene name	AVPR2 (HGNC Symbol)
Synonyms	DIR, DIR3, V2R
Description	Arginine vasopressin receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153902531 - 153907166
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126895 (version 83.38)
Entrez gene	554
UniProt	P30518 (UniProt - Evidence at protein level)
neXtProt	NX_P30518
Antibodypedia	AVPR2 antibodies

PROTEIN BROWSER

AVPR2-001	AVPR2-003	AVPR2-004	AVPR2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AVPR2-001 ENSP00000351805 ENST00000358927	P30518 [Direct mapping] Vasopressin V2 receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0003084 [positive regulation of systemic arterial blood pressure] GO:0003091 [renal water homeostasis] GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006833 [water transport] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007588 [excretion] GO:0007599 [hemostasis] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016021 [integral component of membrane] GO:0021537 [telencephalon development] GO:0031398 [positive regulation of protein ubiquitination] GO:0032609 [interferon-gamma production] GO:0032870 [cellular response to hormone stimulus] GO:0034097 [response to cytokine] GO:0035811 [negative regulation of urine volume] GO:0035814 [negative regulation of renal sodium excretion] GO:0042277 [peptide binding] GO:0045777 [positive regulation of blood pressure] GO:0045907 [positive regulation of vasoconstriction] GO:0055085 [transmembrane transport] GO:1901652 [response to peptide] Show all	371 aa 40.3 kDa	No	7
AVPR2-003 ENSP00000359066 ENST00000370049	P30518 [Direct mapping] Vasopressin V2 receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0003091 [renal water homeostasis] GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006833 [water transport] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007588 [excretion] GO:0007599 [hemostasis] GO:0010628 [positive regulation of gene expression] GO:0016021 [integral component of membrane] GO:0031398 [positive regulation of protein ubiquitination] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045907 [positive regulation of vasoconstriction] GO:0055085 [transmembrane transport] GO:1901652 [response to peptide] Show all	309 aa 33.7 kDa	No	6
AVPR2-004 ENSP00000393513 ENST00000430697	C9JV81 [Direct mapping] Vasopressin V2 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045907 [positive regulation of vasoconstriction] GO:1901652 [response to peptide] Show all	372 aa 39.9 kDa	No	6
AVPR2-201 ENSP00000338072 ENST00000337474	P30518 [Direct mapping] Vasopressin V2 receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0003091 [renal water homeostasis] GO:0004930 [G-protein coupled receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006833 [water transport] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007588 [excretion] GO:0007599 [hemostasis] GO:0010628 [positive regulation of gene expression] GO:0016021 [integral component of membrane] GO:0031398 [positive regulation of protein ubiquitination] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045907 [positive regulation of vasoconstriction] GO:0055085 [transmembrane transport] GO:1901652 [response to peptide] Show all	371 aa 40.3 kDa	No	7