Cell atlas - ZC4H2 - The Human Protein Atlas

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ZC4H2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Vesicles

Human cell
	Microtubules
	Vesicles

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GENERAL INFORMATION
Gene name	ZC4H2
Gene description	Zinc finger, C4H2 domain containing
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules & vesicles.
RNA cell category	Cell line enhanced (NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Microtubules (approved)
Mouse	Localized to the Nucleoli, Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049584
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules & vesicles.

Main location

Vesicles (approved), Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049584	HEK 293	Vesicles
	HPA049584	HEK 293	Microtubules
	HPA049584	PC-3	Microtubules
	HPA049584	U-2 OS	Vesicles

MOUSE CELLS

Main location

Nucleoli, Vesicles

Mouse gene

ENSMUSG00000035062 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049584	NIH 3T3	Nucleoli
	HPA049584	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	ZC4H2 (HGNC Symbol)
Synonyms	HCA127, KIAA1166, WWS
Description	Zinc finger, C4H2 domain containing (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	q11.2
Chromosome location (bp)	64915802 - 65034713
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126970 (version 83.38)
Entrez gene	55906
UniProt	Q9NQZ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQZ6
Antibodypedia	ZC4H2 antibodies

PROTEIN BROWSER

ZC4H2-001	ZC4H2-002	ZC4H2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZC4H2-001 ENSP00000363972 ENST00000374839	Q9NQZ6 [Direct mapping] Zinc finger C4H2 domain-containing protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0007528 [neuromuscular junction development] GO:0021522 [spinal cord motor neuron differentiation] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] GO:0046872 [metal ion binding] Show all	224 aa 26.2 kDa	No	0
ZC4H2-002 ENSP00000338650 ENST00000337990	Q9NQZ6 [Direct mapping] Zinc finger C4H2 domain-containing protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0007528 [neuromuscular junction development] GO:0021522 [spinal cord motor neuron differentiation] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] GO:0046872 [metal ion binding] Show all	201 aa 23.5 kDa	No	0
ZC4H2-201 ENSP00000399126 ENST00000447788	Q9NQZ6 [Direct mapping] Zinc finger C4H2 domain-containing protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0007528 [neuromuscular junction development] GO:0021522 [spinal cord motor neuron differentiation] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] GO:0046872 [metal ion binding] Show all	176 aa 20.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.