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ZC4H2

GENERAL INFORMATION

Gene name

 ZC4H2

Gene description

 Zinc finger, C4H2 domain containing

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (NTERA-2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA049584
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049584

GENE INFORMATION

Gene name

 ZC4H2 (HGNC Symbol)

Synonyms

 HCA127, KIAA1166, WWS

Description

 Zinc finger, C4H2 domain containing (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

 X

Cytoband

 q11.2

Chromosome location (bp)

 64915802 - 65034713

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126970 (version 83.38)

Entrez gene

 55906

UniProt

 Q9NQZ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQZ6

Antibodypedia

 ZC4H2 antibodies

PROTEIN BROWSER
ZC4H2-001
ZC4H2-002
ZC4H2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZC4H2-001
ENSP00000363972
ENST00000374839
Q9NQZ6 [Direct mapping]
Zinc finger C4H2 domain-containing protein
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0030054 [cell junction]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
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 224 aa
26.2 kDa 		No 0
ZC4H2-002
ENSP00000338650
ENST00000337990
Q9NQZ6 [Direct mapping]
Zinc finger C4H2 domain-containing protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0030054 [cell junction]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
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 201 aa
23.5 kDa 		No 0
ZC4H2-201
ENSP00000399126
ENST00000447788
Q9NQZ6 [Direct mapping]
Zinc finger C4H2 domain-containing protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0030054 [cell junction]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
Show all
 176 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.