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FGD3

GENERAL INFORMATION

Gene name

 FGD3

Gene description

 FYVE, RhoGEF and PH domain containing 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1, Karpas-707)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, highest expression in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA020963 , HPA021018
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and cervical cancer (favourable).
Head and neck cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA020963
HPA021018

GENE INFORMATION

Gene name

 FGD3 (HGNC Symbol)

Synonyms

 FLJ00004, ZFYVE5

Description

 FYVE, RhoGEF and PH domain containing 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 92947451 - 93036236

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127084 (version 83.38)

Entrez gene

 89846

UniProt

 Q5JSP0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JSP0

Antibodypedia

 FGD3 antibodies

PROTEIN BROWSER
FGD3-001
FGD3-201
FGD3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGD3-001
ENSP00000364631
ENST00000375482
Q5JSP0 [Direct mapping]
FYVE, RhoGEF and PH domain-containing protein 3
A0A024R252 [Target identity:100%; Query identity:100%]
FYVE, RhoGEF and PH domain containing 3, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0031267 [small GTPase binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046847 [filopodium assembly]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
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 725 aa
79.4 kDa 		No 0
FGD3-201
ENSP00000336914
ENST00000337352
Q5JSP0 [Direct mapping]
FYVE, RhoGEF and PH domain-containing protein 3
A0A024R252 [Target identity:100%; Query identity:100%]
FYVE, RhoGEF and PH domain containing 3, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0031267 [small GTPase binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046847 [filopodium assembly]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 725 aa
79.4 kDa 		No 0
FGD3-202
ENSP00000413833
ENST00000416701
Q5JSP0 [Direct mapping]
FYVE, RhoGEF and PH domain-containing protein 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0031267 [small GTPase binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046847 [filopodium assembly]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 724 aa
79.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.