Expression of PPCS in cancer - Summary - The Human Protein Atlas

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PPCS

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPCS
Gene description	Phosphopantothenoylcysteine synthetase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA031361 , HPA031363
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031361	HPA031363

GENE INFORMATION
Gene name	PPCS (HGNC Symbol)
Synonyms	FLJ11838
Description	Phosphopantothenoylcysteine synthetase (HGNC Symbol)
Entrez gene summary	Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	42456117 - 42473385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127125 (version 83.38)
Entrez gene	79717
UniProt	Q9HAB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAB8
Antibodypedia	PPCS antibodies

PROTEIN BROWSER

PPCS-001	PPCS-002	PPCS-003	PPCS-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPCS-001 ENSP00000361642 ENST00000372561	Q9HAB8 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004632 [phosphopantothenate--cysteine ligase activity] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	311 aa 34 kDa	No	0
PPCS-002 ENSP00000361637 ENST00000372556	Q5VVM2 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.4 kDa	No	0
PPCS-003 ENSP00000361643 ENST00000372562	Q9HAB8 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004632 [phosphopantothenate--cysteine ligase activity] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	138 aa 15.6 kDa	No	0
PPCS-005 ENSP00000361641 ENST00000372560	Q5VVM3 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 22.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.