Tissue expression of PPCS - Summary - The Human Protein Atlas

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PPCS

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PPCS
Gene description	Phosphopantothenoylcysteine synthetase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA031361 , HPA031363
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PPCS (HGNC Symbol)
Synonyms	FLJ11838
Description	Phosphopantothenoylcysteine synthetase (HGNC Symbol)
Entrez gene summary	Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	42456117 - 42473385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127125 (version 83.38)
Entrez gene	79717
UniProt	Q9HAB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAB8
Antibodypedia	PPCS antibodies

PROTEIN BROWSER

PPCS-001	PPCS-002	PPCS-003	PPCS-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPCS-001 ENSP00000361642 ENST00000372561	Q9HAB8 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004632 [phosphopantothenate--cysteine ligase activity] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	311 aa 34 kDa	No	0
PPCS-002 ENSP00000361637 ENST00000372556	Q5VVM2 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.4 kDa	No	0
PPCS-003 ENSP00000361643 ENST00000372562	Q9HAB8 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004632 [phosphopantothenate--cysteine ligase activity] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009108 [coenzyme biosynthetic process] GO:0015937 [coenzyme A biosynthetic process] GO:0015939 [pantothenate metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	138 aa 15.6 kDa	No	0
PPCS-005 ENSP00000361641 ENST00000372560	Q5VVM3 [Direct mapping] Phosphopantothenate--cysteine ligase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 22.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.