We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most malignancies were negative. Prostate, melanoma, urothelial, stomach, pancreatic, liver and female genital cancers showed cases with moderate to strong immunoreactivity.
GENE INFORMATION
Gene name
UBR4 (HGNC Symbol)
Synonyms
KIAA0462, KIAA1307, RBAF600, ZUBR1
Description
Ubiquitin protein ligase E3 component n-recognin 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]