Expression of UBR4 in cancer - Summary - The Human Protein Atlas

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UBR4

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UBR4
Gene description	Ubiquitin protein ligase E3 component n-recognin 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA021046
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021046

GENE INFORMATION
Gene name	UBR4 (HGNC Symbol)
Synonyms	KIAA0462, KIAA1307, RBAF600, ZUBR1
Description	Ubiquitin protein ligase E3 component n-recognin 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	19074506 - 19210276
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127481 (version 83.38)
Entrez gene	23352
UniProt	Q5T4S7 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T4S7
Antibodypedia	UBR4 antibodies

PROTEIN BROWSER

UBR4-001	UBR4-002	UBR4-004	UBR4-005	UBR4-006	UBR4-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBR4-001 ENSP00000364403 ENST00000375254	Q5T4S7 [Direct mapping] E3 ubiquitin-protein ligase UBR4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	5183 aa 573.8 kDa	No	2
UBR4-002 ENSP00000364373 ENST00000375225	Q5TBN9 [Direct mapping] E3 ubiquitin-protein ligase UBR4 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		258 aa 29 kDa	No	0
UBR4-004 ENSP00000364372 ENST00000375224	X6R960 [Direct mapping] E3 ubiquitin-protein ligase UBR4 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		890 aa 100.7 kDa	No	0
UBR4-005 ENSP00000364366 ENST00000375218	Q5T4S7 [Direct mapping] E3 ubiquitin-protein ligase UBR4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	212 aa 24 kDa	No	0
UBR4-006 ENSP00000395313 ENST00000425413	X6RE05 [Direct mapping] E3 ubiquitin-protein ligase UBR4 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		984 aa 106.4 kDa	No	0
UBR4-007 ENSP00000404897 ENST00000417040	A0A0A0MSW0 [Direct mapping] E3 ubiquitin-protein ligase UBR4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	2058 aa 225 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.