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UBR4

GENERAL INFORMATION

Gene name

 UBR4

Gene description

 Ubiquitin protein ligase E3 component n-recognin 4

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021046
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBR4 (HGNC Symbol)

Synonyms

 KIAA0462, KIAA1307, RBAF600, ZUBR1

Description

 Ubiquitin protein ligase E3 component n-recognin 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 19074506 - 19210276

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127481 (version 83.38)

Entrez gene

 23352

UniProt

 Q5T4S7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5T4S7

Antibodypedia

 UBR4 antibodies

PROTEIN BROWSER
UBR4-001
UBR4-002
UBR4-004
UBR4-005
UBR4-006
UBR4-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBR4-001
ENSP00000364403
ENST00000375254
Q5T4S7 [Direct mapping]
E3 ubiquitin-protein ligase UBR4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 5183 aa
573.8 kDa 		No 2
UBR4-002
ENSP00000364373
ENST00000375225
Q5TBN9 [Direct mapping]
E3 ubiquitin-protein ligase UBR4
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 258 aa
29 kDa 		No 0
UBR4-004
ENSP00000364372
ENST00000375224
X6R960 [Direct mapping]
E3 ubiquitin-protein ligase UBR4
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 890 aa
100.7 kDa 		No 0
UBR4-005
ENSP00000364366
ENST00000375218
Q5T4S7 [Direct mapping]
E3 ubiquitin-protein ligase UBR4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 212 aa
24 kDa 		No 0
UBR4-006
ENSP00000395313
ENST00000425413
X6RE05 [Direct mapping]
E3 ubiquitin-protein ligase UBR4
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 984 aa
106.4 kDa 		No 0
UBR4-007
ENSP00000404897
ENST00000417040
A0A0A0MSW0 [Direct mapping]
E3 ubiquitin-protein ligase UBR4
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 2058 aa
225 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.