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PPAT

GENERAL INFORMATION

Gene name

 PPAT

Gene description

 Phosphoribosyl pyrophosphate amidotransferase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA036091 , HPA036092
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable), thyroid cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
Thyroid cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036091
HPA036092

GENE INFORMATION

Gene name

 PPAT (HGNC Symbol)

Synonyms

 GPAT, PRAT

Description

 Phosphoribosyl pyrophosphate amidotransferase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 56393362 - 56435615

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128059 (version 83.38)

Entrez gene

 5471

UniProt

 Q06203 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06203

Antibodypedia

 PPAT antibodies

PROTEIN BROWSER
PPAT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPAT-001
ENSP00000264220
ENST00000264220
Q06203 [Direct mapping]
Amidophosphoribosyltransferase
A8K4H7 [Target identity:100%; Query identity:100%]
Amidophosphoribosyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0001822 [kidney development]
GO:0004044 [amidophosphoribosyltransferase activity]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0006543 [glutamine catabolic process]
GO:0007595 [lactation]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009116 [nucleoside metabolic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019693 [ribose phosphate metabolic process]
GO:0031100 [organ regeneration]
GO:0032869 [cellular response to insulin stimulus]
GO:0035690 [cellular response to drug]
GO:0042493 [response to drug]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0060135 [maternal process involved in female pregnancy]
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 517 aa
57.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.