Cell atlas - PPAT - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PPAT

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody ring

Human cell
	Microtubules

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PPAT
Gene description	Phosphoribosyl pyrophosphate amidotransferase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the midbody ring.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Midbody ring (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036091
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the midbody ring.

Main location

Midbody ring (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036091	A-431	Midbody ring	Intensity	Intensity
	HPA036091	U-2 OS	Midbody ring	Intensity	Intensity
	HPA036091	U-251 MG	No staining

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	PPAT (HGNC Symbol)
Synonyms	GPAT, PRAT
Description	Phosphoribosyl pyrophosphate amidotransferase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	56393362 - 56435615
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128059 (version 83.38)
Entrez gene	5471
UniProt	Q06203 (UniProt - Evidence at protein level)
neXtProt	NX_Q06203
Antibodypedia	PPAT antibodies

PROTEIN BROWSER

PPAT-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPAT-001 ENSP00000264220 ENST00000264220	Q06203 [Direct mapping] Amidophosphoribosyltransferase A8K4H7 [Target identity:100%; Query identity:100%] Amidophosphoribosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001822 [kidney development] GO:0004044 [amidophosphoribosyltransferase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006164 [purine nucleotide biosynthetic process] GO:0006189 ['de novo' IMP biosynthetic process] GO:0006543 [glutamine catabolic process] GO:0007595 [lactation] GO:0009113 [purine nucleobase biosynthetic process] GO:0009116 [nucleoside metabolic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0019693 [ribose phosphate metabolic process] GO:0031100 [organ regeneration] GO:0032869 [cellular response to insulin stimulus] GO:0035690 [cellular response to drug] GO:0042493 [response to drug] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051289 [protein homotetramerization] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0060135 [maternal process involved in female pregnancy] Show all	517 aa 57.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.