Cell atlas - RFPL1 - The Human Protein Atlas

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RFPL1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	RFPL1
Gene description	Ret finger protein-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HDLM-2, SH-SY5Y, THP-1, HMC-1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nuclear speckles (approved)
Additional location	In addition localized to the Plasma membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA048320 , HPA072380
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, SH-SY5Y, THP-1, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nuclear speckles (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA048320	SH-SY5Y	Nuclear speckles
HPA048320	SiHa	Nuclear speckles
HPA048320	U-2 OS	Nuclear speckles	Intensity
HPA072380	SH-SY5Y	Nuclear speckles
HPA072380	SiHa	Nuclear speckles
HPA072380	SiHa	Plasma membrane
HPA072380	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	RFPL1 (HGNC Symbol)
Synonyms	RNF78
Description	Ret finger protein-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q12.2
Chromosome location (bp)	29438583 - 29442455
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000128250 (version 83.38)
Entrez gene	5988
UniProt	O75677 (UniProt - Evidence at transcript level)
neXtProt	NX_O75677
Antibodypedia	RFPL1 antibodies

PROTEIN BROWSER

RFPL1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RFPL1-001 ENSP00000346342 ENST00000354373	O75677 [Direct mapping] Ret finger protein-like 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	317 aa 35.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.