Cell atlas - A4GALT - The Human Protein Atlas

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A4GALT

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	A4GALT
Gene description	Alpha 1,4-galactosyltransferase
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA001141 , HPA076542
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001141	HeLa	Mitochondria
	HPA001141	MCF7	Mitochondria	Intensity
	HPA076542	A549	Mitochondria
	HPA076542	U-2 OS	Nuclear bodies
	HPA076542	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	A4GALT (HGNC Symbol)
Synonyms	A14GALT, Gb3S, P(k)
Description	Alpha 1,4-galactosyltransferase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	42692121 - 42721298
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128274 (version 83.38)
Entrez gene	53947
UniProt	Q9NPC4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NPC4
Antibodypedia	A4GALT antibodies

PROTEIN BROWSER

A4GALT-001	A4GALT-003	A4GALT-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
A4GALT-001 ENSP00000249005 ENST00000249005	Q9NPC4 [Direct mapping] Lactosylceramide 4-alpha-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0006688 [glycosphingolipid biosynthetic process] GO:0007009 [plasma membrane organization] GO:0008378 [galactosyltransferase activity] GO:0016020 [membrane] GO:0030173 [integral component of Golgi membrane] GO:0050512 [lactosylceramide 4-alpha-galactosyltransferase activity] GO:0070062 [extracellular exosome] Show all	353 aa 40.5 kDa	No	1
A4GALT-003 ENSP00000370678 ENST00000381278	Q9NPC4 [Direct mapping] Lactosylceramide 4-alpha-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0006688 [glycosphingolipid biosynthetic process] GO:0007009 [plasma membrane organization] GO:0008378 [galactosyltransferase activity] GO:0016020 [membrane] GO:0030173 [integral component of Golgi membrane] GO:0050512 [lactosylceramide 4-alpha-galactosyltransferase activity] GO:0070062 [extracellular exosome] Show all	353 aa 40.5 kDa	No	1
A4GALT-004 ENSP00000384794 ENST00000401850	Q9NPC4 [Direct mapping] Lactosylceramide 4-alpha-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001576 [globoside biosynthetic process] GO:0006486 [protein glycosylation] GO:0006688 [glycosphingolipid biosynthetic process] GO:0007009 [plasma membrane organization] GO:0008378 [galactosyltransferase activity] GO:0015643 [toxic substance binding] GO:0016020 [membrane] GO:0030173 [integral component of Golgi membrane] GO:0050512 [lactosylceramide 4-alpha-galactosyltransferase activity] GO:0070062 [extracellular exosome] Show all	353 aa 40.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.