Cell atlas - APOL2 - The Human Protein Atlas

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APOL2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	APOL2
Gene description	Apolipoprotein L, 2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001078
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the nuclear bodies.

Main location

Nucleoplasm (approved), Cytosol (approved)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001078	A-431	Nucleoplasm
	HPA001078	A-431	Cytosol
	HPA001078	U-2 OS	Nucleoplasm
			Nuclear bodies
			Cytosol
	HPA001078	U-251 MG	Nucleoplasm
			Nuclear bodies
			Cytosol

GENE INFORMATION
Gene name	APOL2 (HGNC Symbol)
Synonyms	APOL-II
Description	Apolipoprotein L, 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	36226203 - 36239954
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128335 (version 83.38)
Entrez gene	23780
UniProt	Q9BQE5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQE5
Antibodypedia	APOL2 antibodies

PROTEIN BROWSER

APOL2-001	APOL2-002	APOL2-006	APOL2-008	APOL2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOL2-001 ENSP00000249066 ENST00000249066	Q9BQE5 [Direct mapping] Apolipoprotein L2 A0A024R1M8 [Target identity:100%; Query identity:100%] Apolipoprotein L, 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0006953 [acute-phase response] GO:0007275 [multicellular organismal development] GO:0008035 [high-density lipoprotein particle binding] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0060135 [maternal process involved in female pregnancy] Show all	337 aa 37.1 kDa	No	2
APOL2-002 ENSP00000351292 ENST00000358502	Q9BQE5 [Direct mapping] Apolipoprotein L2 A0A024R1M8 [Target identity:100%; Query identity:100%] Apolipoprotein L, 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0006953 [acute-phase response] GO:0007275 [multicellular organismal development] GO:0008035 [high-density lipoprotein particle binding] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0060135 [maternal process involved in female pregnancy] Show all	337 aa 37.1 kDa	No	2
APOL2-006 ENSP00000400486 ENST00000454728	B0QYK8 [Direct mapping] Apolipoprotein L2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	74 aa 8.7 kDa	No	0
APOL2-008 ENSP00000403153 ENST00000451256	J3KQL8 [Direct mapping] Apolipoprotein L2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0042157 [lipoprotein metabolic process] Show all	449 aa 48.9 kDa	No	2
APOL2-009 ENSP00000431231 ENST00000529194	E9PM95 [Direct mapping] Apolipoprotein L2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	128 aa 14.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.