Expression of APOL2 in cancer - Summary - The Human Protein Atlas

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APOL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	APOL2
Gene description	Apolipoprotein L, 2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA001078
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001078

GENE INFORMATION
Gene name	APOL2 (HGNC Symbol)
Synonyms	APOL-II
Description	Apolipoprotein L, 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	36226203 - 36239954
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128335 (version 83.38)
Entrez gene	23780
UniProt	Q9BQE5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQE5
Antibodypedia	APOL2 antibodies

PROTEIN BROWSER

APOL2-001	APOL2-002	APOL2-006	APOL2-008	APOL2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOL2-001 ENSP00000249066 ENST00000249066	Q9BQE5 [Direct mapping] Apolipoprotein L2 A0A024R1M8 [Target identity:100%; Query identity:100%] Apolipoprotein L, 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0006953 [acute-phase response] GO:0007275 [multicellular organismal development] GO:0008035 [high-density lipoprotein particle binding] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0060135 [maternal process involved in female pregnancy] Show all	337 aa 37.1 kDa	No	2
APOL2-002 ENSP00000351292 ENST00000358502	Q9BQE5 [Direct mapping] Apolipoprotein L2 A0A024R1M8 [Target identity:100%; Query identity:100%] Apolipoprotein L, 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0006953 [acute-phase response] GO:0007275 [multicellular organismal development] GO:0008035 [high-density lipoprotein particle binding] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0060135 [maternal process involved in female pregnancy] Show all	337 aa 37.1 kDa	No	2
APOL2-006 ENSP00000400486 ENST00000454728	B0QYK8 [Direct mapping] Apolipoprotein L2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	74 aa 8.7 kDa	No	0
APOL2-008 ENSP00000403153 ENST00000451256	J3KQL8 [Direct mapping] Apolipoprotein L2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0042157 [lipoprotein metabolic process] Show all	449 aa 48.9 kDa	No	2
APOL2-009 ENSP00000431231 ENST00000529194	E9PM95 [Direct mapping] Apolipoprotein L2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	128 aa 14.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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