Expression of RNF112 in cancer - Summary - The Human Protein Atlas

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RNF112

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF112
Gene description	Ring finger protein 112
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (SCLC-21H, SH-SY5Y, U-87 MG)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in Purkinje cells of cerebellum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA015970
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015970

GENE INFORMATION
Gene name	RNF112 (HGNC Symbol)
Synonyms	BFP, ZNF179
Description	Ring finger protein 112 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19411125 - 19417276
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000128482 (version 83.38)
Entrez gene	7732
UniProt	Q9ULX5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9ULX5
Antibodypedia	RNF112 antibodies

PROTEIN BROWSER

RNF112-001	RNF112-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF112-001 ENSP00000454919 ENST00000461366	Q9ULX5 [Direct mapping] RING finger protein 112 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0045666 [positive regulation of neuron differentiation] GO:0045687 [positive regulation of glial cell differentiation] GO:0046872 [metal ion binding] GO:0071158 [positive regulation of cell cycle arrest] Show all	631 aa 68.3 kDa	No	1
RNF112-005 ENSP00000464134 ENST00000575165	J3QRB8 [Direct mapping] RING finger protein 112 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	123 aa 13.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.