Expression of MKLN1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MKLN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MKLN1
Gene description	Muskelin 1, intracellular mediator containing kelch motifs
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA022817
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022817

GENE INFORMATION
Gene name	MKLN1 (HGNC Symbol)
Synonyms	TWA2
Description	Muskelin 1, intracellular mediator containing kelch motifs (HGNC Symbol)
Entrez gene summary	Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	q32.3
Chromosome location (bp)	131110096 - 131496636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128585 (version 83.38)
Entrez gene	4289
UniProt	Q9UL63 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL63
Antibodypedia	MKLN1 antibodies

PROTEIN BROWSER

MKLN1-001	MKLN1-007	MKLN1-012	MKLN1-013	MKLN1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKLN1-001 ENSP00000323527 ENST00000352689	Q9UL63 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0008360 [regulation of cell shape] GO:0031532 [actin cytoskeleton reorganization] Show all	735 aa 84.8 kDa	No	0
MKLN1-007 ENSP00000412815 ENST00000446815	C9JVL5 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 11.7 kDa	No	0
MKLN1-012 ENSP00000398094 ENST00000421797	C9J7E8 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	643 aa 74.5 kDa	No	0
MKLN1-013 ENSP00000387920 ENST00000416992	C9JXB0 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	126 aa 15 kDa	No	0
MKLN1-014 ENSP00000399954 ENST00000429546	C9JWX9 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 9.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.