Tissue expression of MKLN1 - Summary - The Human Protein Atlas

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MKLN1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MKLN1
Gene description	Muskelin 1, intracellular mediator containing kelch motifs
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA022817
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MKLN1 (HGNC Symbol)
Synonyms	TWA2
Description	Muskelin 1, intracellular mediator containing kelch motifs (HGNC Symbol)
Entrez gene summary	Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	q32.3
Chromosome location (bp)	131110096 - 131496636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128585 (version 83.38)
Entrez gene	4289
UniProt	Q9UL63 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL63
Antibodypedia	MKLN1 antibodies

PROTEIN BROWSER

MKLN1-001	MKLN1-007	MKLN1-012	MKLN1-013	MKLN1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKLN1-001 ENSP00000323527 ENST00000352689	Q9UL63 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0008360 [regulation of cell shape] GO:0031532 [actin cytoskeleton reorganization] Show all	735 aa 84.8 kDa	No	0
MKLN1-007 ENSP00000412815 ENST00000446815	C9JVL5 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 11.7 kDa	No	0
MKLN1-012 ENSP00000398094 ENST00000421797	C9J7E8 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	643 aa 74.5 kDa	No	0
MKLN1-013 ENSP00000387920 ENST00000416992	C9JXB0 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	126 aa 15 kDa	No	0
MKLN1-014 ENSP00000399954 ENST00000429546	C9JWX9 [Direct mapping] Muskelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 9.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.