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MYO1B

GENERAL INFORMATION

Gene name

 MYO1B

Gene description

 Myosin IB

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA013607 , HPA060144
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013607
HPA060144

GENE INFORMATION

Gene name

 MYO1B (HGNC Symbol)

Synonyms

 myr1

Description

 Myosin IB (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q32.3

Chromosome location (bp)

 191245185 - 191425389

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128641 (version 83.38)

Entrez gene

 4430

UniProt

 O43795 (UniProt - Evidence at protein level)

neXtProt

 NX_O43795

Antibodypedia

 MYO1B antibodies

PROTEIN BROWSER
MYO1B-001
MYO1B-002
MYO1B-003
MYO1B-005
MYO1B-008
MYO1B-009
MYO1B-010
MYO1B-011
MYO1B-012
MYO1B-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYO1B-001
ENSP00000306382
ENST00000304164
O43795 [Direct mapping]
Unconventional myosin-Ib
B0I1S9 [Target identity:100%; Query identity:100%]
MYO1B variant protein; Myosin IB, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007015 [actin filament organization]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016459 [myosin complex]
GO:0030048 [actin filament-based movement]
GO:0030175 [filopodium]
GO:0032588 [trans-Golgi network membrane]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
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 1136 aa
132 kDa 		No 0
MYO1B-002
ENSP00000376130
ENST00000392316
E9PDF6 [Direct mapping]
Unconventional myosin-Ib
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 1107 aa
128.5 kDa 		No 0
MYO1B-003
ENSP00000341903
ENST00000339514
O43795 [Direct mapping]
Unconventional myosin-Ib
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007015 [actin filament organization]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016459 [myosin complex]
GO:0030048 [actin filament-based movement]
GO:0030175 [filopodium]
GO:0032588 [trans-Golgi network membrane]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
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 1078 aa
125 kDa 		No 0
MYO1B-005
ENSP00000388140
ENST00000451437
E7EQD9 [Direct mapping]
Unconventional myosin-Ib
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 303 aa
34.1 kDa 		No 0
MYO1B-008
ENSP00000387610
ENST00000420448
C9K0I9 [Direct mapping]
Unconventional myosin-Ib
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 83 aa
9.7 kDa 		No 0
MYO1B-009
ENSP00000408454
ENST00000427152
H7C2Y7 [Direct mapping]
Unconventional myosin-Ib
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003774 [motor activity]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 192 aa
21.7 kDa 		No 0
MYO1B-010
ENSP00000376132
ENST00000392318
O43795 [Direct mapping]
Unconventional myosin-Ib
B0I1S9 [Target identity:100%; Query identity:100%]
MYO1B variant protein; Myosin IB, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007015 [actin filament organization]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016459 [myosin complex]
GO:0030048 [actin filament-based movement]
GO:0030175 [filopodium]
GO:0030898 [actin-dependent ATPase activity]
GO:0032588 [trans-Golgi network membrane]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
Show all
 1136 aa
132 kDa 		No 0
MYO1B-011
ENSP00000401324
ENST00000418908
C9JYW1 [Direct mapping]
Unconventional myosin-Ib
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 163 aa
18.3 kDa 		No 0
MYO1B-012
ENSP00000399459
ENST00000438652
C9JUP5 [Direct mapping]
Unconventional myosin-Ib
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 149 aa
16.8 kDa 		No 0
MYO1B-015
ENSP00000489544
ENST00000634375
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0016459 [myosin complex]
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 189 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.