Cell atlas - EIF2AK4 - The Human Protein Atlas

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EIF2AK4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	EIF2AK4
Gene description	Eukaryotic translation initiation factor 2 alpha kinase 4
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA011811
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011811	A-431	Cytosol
	HPA011811	U-2 OS	Cytosol
	HPA011811	U-251 MG	Cytosol

GENE INFORMATION
Gene name	EIF2AK4 (HGNC Symbol)
Synonyms	GCN2, KIAA1338
Description	Eukaryotic translation initiation factor 2 alpha kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	39934146 - 40035591
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128829 (version 83.38)
Entrez gene	440275
UniProt	Q9P2K8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2K8
Antibodypedia	EIF2AK4 antibodies

PROTEIN BROWSER

EIF2AK4-001	EIF2AK4-002	EIF2AK4-003	EIF2AK4-009	EIF2AK4-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF2AK4-001 ENSP00000263791 ENST00000263791	Q9P2K8 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005844 [polysome] GO:0006446 [regulation of translational initiation] GO:0006468 [protein phosphorylation] GO:0009267 [cellular response to starvation] GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation] GO:0017148 [negative regulation of translation] GO:0022626 [cytosolic ribosome] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034198 [cellular response to amino acid starvation] GO:0042803 [protein homodimerization activity] GO:0043558 [regulation of translational initiation in response to stress] GO:0045665 [negative regulation of neuron differentiation] GO:1990138 [neuron projection extension] GO:1990253 [cellular response to leucine starvation] Show all	1649 aa 186.9 kDa	No	0
EIF2AK4-002 ENSP00000453148 ENST00000559624	Q9P2K8 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005844 [polysome] GO:0006446 [regulation of translational initiation] GO:0006468 [protein phosphorylation] GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation] GO:0022626 [cytosolic ribosome] GO:0034198 [cellular response to amino acid starvation] GO:0045665 [negative regulation of neuron differentiation] GO:1990138 [neuron projection extension] GO:1990253 [cellular response to leucine starvation] Show all	616 aa 69.8 kDa	No	0
EIF2AK4-003 ENSP00000453575 ENST00000560855	H0YME5 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 4 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	1427 aa 161.1 kDa	No	0
EIF2AK4-009 ENSP00000454210 ENST00000558823	H0YNY9 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9.5 kDa	No	0
EIF2AK4-010 ENSP00000453968 ENST00000560648	H0YND8 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	136 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.