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EIF2AK4

GENERAL INFORMATION

Gene name

 EIF2AK4

Gene description

 Eukaryotic translation initiation factor 2 alpha kinase 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, additional positivity in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA011811
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA011811

GENE INFORMATION

Gene name

 EIF2AK4 (HGNC Symbol)

Synonyms

 GCN2, KIAA1338

Description

 Eukaryotic translation initiation factor 2 alpha kinase 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 39934146 - 40035591

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128829 (version 83.38)

Entrez gene

 440275

UniProt

 Q9P2K8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2K8

Antibodypedia

 EIF2AK4 antibodies

PROTEIN BROWSER
EIF2AK4-001
EIF2AK4-002
EIF2AK4-003
EIF2AK4-009
EIF2AK4-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF2AK4-001
ENSP00000263791
ENST00000263791
Q9P2K8 [Direct mapping]
Eukaryotic translation initiation factor 2-alpha kinase 4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005844 [polysome]
GO:0006446 [regulation of translational initiation]
GO:0006468 [protein phosphorylation]
GO:0009267 [cellular response to starvation]
GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation]
GO:0017148 [negative regulation of translation]
GO:0022626 [cytosolic ribosome]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034198 [cellular response to amino acid starvation]
GO:0042803 [protein homodimerization activity]
GO:0043558 [regulation of translational initiation in response to stress]
GO:0045665 [negative regulation of neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990253 [cellular response to leucine starvation]
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 1649 aa
186.9 kDa 		No 0
EIF2AK4-002
ENSP00000453148
ENST00000559624
Q9P2K8 [Direct mapping]
Eukaryotic translation initiation factor 2-alpha kinase 4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005844 [polysome]
GO:0006446 [regulation of translational initiation]
GO:0006468 [protein phosphorylation]
GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation]
GO:0022626 [cytosolic ribosome]
GO:0034198 [cellular response to amino acid starvation]
GO:0045665 [negative regulation of neuron differentiation]
GO:1990138 [neuron projection extension]
GO:1990253 [cellular response to leucine starvation]
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 616 aa
69.8 kDa 		No 0
EIF2AK4-003
ENSP00000453575
ENST00000560855
H0YME5 [Direct mapping]
Eukaryotic translation initiation factor 2-alpha kinase 4
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 1427 aa
161.1 kDa 		No 0
EIF2AK4-009
ENSP00000454210
ENST00000558823
H0YNY9 [Direct mapping]
Eukaryotic translation initiation factor 2-alpha kinase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 80 aa
9.5 kDa 		No 0
EIF2AK4-010
ENSP00000453968
ENST00000560648
H0YND8 [Direct mapping]
Eukaryotic translation initiation factor 2-alpha kinase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 136 aa
15.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.