Expression of DCTD in cancer - Summary - The Human Protein Atlas

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DCTD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DCTD
Gene description	DCMP deaminase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA035894
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035894

GENE INFORMATION
Gene name	DCTD
Synonyms
Description	DCMP deaminase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q35.1
Chromosome location (bp)	182890060 - 182917936
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129187 (version 83.38)
Entrez gene	1635
UniProt	P32321 (UniProt - Evidence at protein level)
neXtProt	NX_P32321
Antibodypedia	DCTD antibodies

PROTEIN BROWSER

DCTD-001	DCTD-002	DCTD-006	DCTD-007	DCTD-008	DCTD-009	DCTD-013	DCTD-014	DCTD-015	DCTD-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCTD-001 ENSP00000349576 ENST00000357067	P32321 [Direct mapping] Deoxycytidylate deaminase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004132 [dCMP deaminase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0008270 [zinc ion binding] GO:0009165 [nucleotide biosynthetic process] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046134 [pyrimidine nucleoside biosynthetic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	189 aa 21 kDa	No	0
DCTD-002 ENSP00000398194 ENST00000438320	P32321 [Direct mapping] Deoxycytidylate deaminase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004132 [dCMP deaminase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0008270 [zinc ion binding] GO:0009165 [nucleotide biosynthetic process] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046134 [pyrimidine nucleoside biosynthetic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	178 aa 20 kDa	No	0
DCTD-006 ENSP00000422662 ENST00000503182	D6RBJ9 [Direct mapping] Deoxycytidylate deaminase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004132 [dCMP deaminase activity] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0008270 [zinc ion binding] GO:0016787 [hydrolase activity] Show all	169 aa 19 kDa	No	0
DCTD-007 ENSP00000423182 ENST00000512766	D6R9S0 [Direct mapping] Deoxycytidylate deaminase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004132 [dCMP deaminase activity] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0008270 [zinc ion binding] GO:0016787 [hydrolase activity] Show all	119 aa 13.4 kDa	No	0
DCTD-008 ENSP00000427282 ENST00000508994	D6RJA9 [Direct mapping] Deoxycytidylate deaminase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.8 kDa	No	0
DCTD-009 ENSP00000424017 ENST00000510370	P32321 [Direct mapping] Deoxycytidylate deaminase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004132 [dCMP deaminase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0008270 [zinc ion binding] GO:0009165 [nucleotide biosynthetic process] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0046134 [pyrimidine nucleoside biosynthetic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	178 aa 20 kDa	No	0
DCTD-013 ENSP00000422729 ENST00000503988	D6RAD7 [Direct mapping] Deoxycytidylate deaminase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] Show all	59 aa 6.5 kDa	No	0
DCTD-014 ENSP00000421792 ENST00000503820	D6RAR9 [Direct mapping] Deoxycytidylate deaminase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] Show all	73 aa 8.2 kDa	No	0
DCTD-015 ENSP00000424050 ENST00000510307	D6RBN2 [Direct mapping] Deoxycytidylate deaminase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004132 [dCMP deaminase activity] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0008270 [zinc ion binding] GO:0016787 [hydrolase activity] Show all	120 aa 13.4 kDa	No	0
DCTD-016 ENSP00000423894 ENST00000514754	D6RC36 [Direct mapping] Deoxycytidylate deaminase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] Show all	98 aa 11 kDa	No	0

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