Cell atlas - FAM64A - The Human Protein Atlas

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FAM64A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FAM64A
Gene description	Family with sequence similarity 64, member A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)
Additional location	In addition localized to the Nucleoli (supported), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by correlation analysis and custom assay

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA043783 , HPA049934
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.

Main location

Nucleus (validated)

Additional location

Nucleoli (supported), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA043783	A-431	Nucleus
HPA043783	A-431	Cytosol
HPA043783	U-2 OS	Nucleus	Intensity	Intensity
HPA043783	U-251 MG	Nucleus	Intensity
HPA043783	U-251 MG	Cytosol
HPA049934	PC-3	Nucleus	Intensity
HPA049934	U-2 OS	Nucleus
HPA049934	U-251 MG	Nucleus	Intensity
HPA049934	U-251 MG	Nucleoli	Intensity

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA049934	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. FAM64A is mostly expressed during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to correlation analysis and custom assay
Intensity variation	Nucleoli, Nucleus
HPA043783

GENE INFORMATION
Gene name	FAM64A (HGNC Symbol)
Synonyms	CATS, FLJ10156, FLJ10491, RCS1
Description	Family with sequence similarity 64, member A (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	6444415 - 6451469
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129195 (version 83.38)
Entrez gene	54478
UniProt	Q9BSJ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BSJ6
Antibodypedia	FAM64A antibodies

PROTEIN BROWSER

FAM64A-003	FAM64A-006	FAM64A-008	FAM64A-009	FAM64A-012	FAM64A-013	FAM64A-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM64A-003 ENSP00000458584 ENST00000572595	I3L156 [Direct mapping] Protein FAM64A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] Show all	279 aa 30.9 kDa	No	0
FAM64A-006 ENSP00000459860 ENST00000571572	I3L2R2 [Direct mapping] Protein FAM64A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.2 kDa	No	0
FAM64A-008 ENSP00000250056 ENST00000250056	Q9BSJ6 [Direct mapping] Protein FAM64A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	248 aa 27.5 kDa	No	0
FAM64A-009 ENSP00000459235 ENST00000572447	Q9BSJ6 [Direct mapping] Protein FAM64A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	238 aa 26.2 kDa	No	0
FAM64A-012 ENSP00000459597 ENST00000571373	I3L419 [Direct mapping] Protein FAM64A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	247 aa 27.2 kDa	No	0
FAM64A-013 ENSP00000460894 ENST00000570337	I3L419 [Direct mapping] Protein FAM64A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	247 aa 27.2 kDa	No	0
FAM64A-014 ENSP00000458534 ENST00000576056	Q9BSJ6 [Direct mapping] Protein FAM64A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0051301 [cell division] Show all	238 aa 26.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.