Expression of RPAIN in cancer - Summary - The Human Protein Atlas

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RPAIN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RPAIN
Gene description	RPA interacting protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA023924 , HPA031526
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable) and pancreatic cancer (favourable).
Prostate cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023924	HPA031526

GENE INFORMATION
Gene name	RPAIN (HGNC Symbol)
Synonyms	hRIP, MGC4189, RIP
Description	RPA interacting protein (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	5419641 - 5432876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129197 (version 83.38)
Entrez gene	84268
UniProt	Q86UA6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UA6
Antibodypedia	RPAIN antibodies

PROTEIN BROWSER

RPAIN-001	RPAIN-002	RPAIN-003	RPAIN-012	RPAIN-014	RPAIN-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPAIN-001 ENSP00000370606 ENST00000381209	A0A0B4J1T3 [Direct mapping] RPA interacting protein, isoform CRA_a; RPA-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		219 aa 24.8 kDa	No	0
RPAIN-002 ENSP00000370605 ENST00000381208	E9PDG9 [Direct mapping] RPA-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] Show all	172 aa 19.7 kDa	No	0
RPAIN-003 ENSP00000439939 ENST00000536255	Q86UA6 [Direct mapping] RPA-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006261 [DNA-dependent DNA replication] GO:0006281 [DNA repair] GO:0006310 [DNA recombination] GO:0006606 [protein import into nucleus] GO:0009411 [response to UV] GO:0016605 [PML body] GO:0032403 [protein complex binding] GO:0046872 [metal ion binding] Show all	106 aa 12.3 kDa	No	0
RPAIN-012 ENSP00000385814 ENST00000405578	A0A0A0MSE7 [Direct mapping] RPA-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		231 aa 26.2 kDa	No	0
RPAIN-014 ENSP00000315069 ENST00000327154	A0A0A0MR35 [Direct mapping] RPA-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 17.1 kDa	No	0
RPAIN-017 ENSP00000467178 ENST00000574003	F5H3Q7 [Direct mapping] RPA-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] Show all	106 aa 12.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.