Fields »
ABOUT
HELP
BLOG
USP6

GENERAL INFORMATION

Gene name

 USP6

Gene description

 Ubiquitin specific peptidase 6

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA046969
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046969

GENE INFORMATION

Gene name

 USP6 (HGNC Symbol)

Synonyms

 HRP1, Tre-2, TRE17, Tre2, TRESMCR

Description

 Ubiquitin specific peptidase 6 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 5116438 - 5175034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129204 (version 83.38)

Entrez gene

 9098

UniProt

 P35125 (UniProt - Evidence at protein level)

neXtProt

 NX_P35125

Antibodypedia

 USP6 antibodies

PROTEIN BROWSER
USP6-001
USP6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP6-001
ENSP00000250066
ENST00000250066
P35125 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0055037 [recycling endosome]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 1406 aa
158.7 kDa 		No 0
USP6-002
ENSP00000460380
ENST00000574788
P35125 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Show all
GO:0003676 [nucleic acid binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0055037 [recycling endosome]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 1406 aa
158.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.