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PLD2

GENERAL INFORMATION

Gene name

 PLD2

Gene description

 Phospholipase D2

Protein class

 Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA013397
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PLD2

Synonyms

Description

 Phospholipase D2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4807096 - 4823434

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129219 (version 83.38)

Entrez gene

 5338

UniProt

 O14939 (UniProt - Evidence at protein level)

neXtProt

 NX_O14939

Antibodypedia

 PLD2 antibodies

PROTEIN BROWSER
PLD2-001
PLD2-004
PLD2-012
PLD2-013
PLD2-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLD2-001
ENSP00000263088
ENST00000263088
O14939 [Direct mapping]
Phospholipase D2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002031 [G-protein coupled receptor internalization]
GO:0003824 [catalytic activity]
GO:0004630 [phospholipase D activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006643 [membrane lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006655 [phosphatidylglycerol biosynthetic process]
GO:0006887 [exocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007010 [cytoskeleton organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009395 [phospholipid catabolic process]
GO:0030334 [regulation of cell migration]
GO:0031526 [brush border membrane]
GO:0031982 [vesicle]
GO:0035091 [phosphatidylinositol binding]
GO:0036465 [synaptic vesicle recycling]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046473 [phosphatidic acid metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048017 [inositol lipid-mediated signaling]
GO:0048870 [cell motility]
GO:0050764 [regulation of phagocytosis]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity]
Show all
 933 aa
106 kDa 		No 0
PLD2-004
ENSP00000458795
ENST00000575316
I3L1F3 [Direct mapping]
Phospholipase D2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
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 172 aa
19.3 kDa 		No 0
PLD2-012
ENSP00000460250
ENST00000576983
I3L381 [Direct mapping]
Phospholipase D2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
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 196 aa
21.7 kDa 		No 0
PLD2-013
ENSP00000460477
ENST00000576864
I3L3I7 [Direct mapping]
Phospholipase D2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 197 aa
22.1 kDa 		No 0
PLD2-015
ENSP00000459571
ENST00000572940
O14939 [Direct mapping]
Phospholipase D2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004630 [phospholipase D activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006643 [membrane lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006655 [phosphatidylglycerol biosynthetic process]
GO:0006887 [exocytosis]
GO:0007010 [cytoskeleton organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009395 [phospholipid catabolic process]
GO:0030334 [regulation of cell migration]
GO:0031982 [vesicle]
GO:0035091 [phosphatidylinositol binding]
GO:0036465 [synaptic vesicle recycling]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046473 [phosphatidic acid metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048017 [inositol lipid-mediated signaling]
GO:0048870 [cell motility]
GO:0050764 [regulation of phagocytosis]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity]
Show all
 922 aa
104.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.