Expression of CD68 in cancer - Summary - The Human Protein Atlas

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CD68

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD68
Gene description	CD68 molecule
Protein class	CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in macrophages.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 5 antibodies. HPA048982 , CAB000051 , CAB000066 , CAB072861 , CAB072862
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048982	CAB000051	CAB000066	CAB072861	CAB072862

GENE INFORMATION
Gene name	CD68 (HGNC Symbol)
Synonyms	DKFZp686M18236, GP110, LAMP4, macrosialin, SCARD1
Description	CD68 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7579467 - 7582113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129226 (version 83.38)
Entrez gene	968
UniProt	P34810 (UniProt - Evidence at protein level)
neXtProt	NX_P34810
Antibodypedia	CD68 antibodies

PROTEIN BROWSER

CD68-001	CD68-002	CD68-004	CD68-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD68-001 ENSP00000250092 ENST00000250092	P34810 [Direct mapping] Macrosialin Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071310 [cellular response to organic substance] Show all	354 aa 37.4 kDa	Yes	1
CD68-002 ENSP00000369867 ENST00000380498	P34810 [Direct mapping] Macrosialin Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	327 aa 34.7 kDa	Yes	1
CD68-004 ENSP00000462198 ENST00000584180	J3KRX0 [Direct mapping] Macrosialin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	121 aa 13.2 kDa	No	0
CD68-005 ENSP00000462768 ENST00000584502	J3KT24 [Direct mapping] Macrosialin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	181 aa 18.6 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.