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FXR2

GENERAL INFORMATION

Gene name

 FXR2

Gene description

 Fragile X mental retardation, autosomal homolog 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression. High expression neuronal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 2 antibodies.
HPA022997 , CAB011205
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FXR2 (HGNC Symbol)

Synonyms

 FMR1L2

Description

 Fragile X mental retardation, autosomal homolog 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7591230 - 7614871

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129245 (version 83.38)

Entrez gene

 9513

UniProt

 P51116 (UniProt - Evidence at protein level)

neXtProt

 NX_P51116

Antibodypedia

 FXR2 antibodies

PROTEIN BROWSER
FXR2-001
FXR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FXR2-001
ENSP00000250113
ENST00000250113
P51116 [Direct mapping]
Fragile X mental retardation syndrome-related protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0030425 [dendrite]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
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 673 aa
74.2 kDa 		No 0
FXR2-002
ENSP00000459230
ENST00000571597
I3L1Z2 [Direct mapping]
Fragile X mental retardation syndrome-related protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0005634 [nucleus]
GO:0005844 [polysome]
GO:0017148 [negative regulation of translation]
Show all
 118 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.